You will find a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors in the dorsal horn to reduce afferent ache transmission and deliver analgesia. Hence, medication like clonidine that target alpha-2 receptors can affect the transmission of suffering. Clonidine is dispersed in breast milk; https://www.proleviate.com/post/the-new-pain-killer-conolidine