Notwithstanding many setbacks, many MDM2 inhibitors have now progressed into late-stage clinical enhancement. New approaches have also been created to enhance the efficacy of MDM2 inhibitors also to mitigate their on-concentrate on toxicity. During this review, we summarize the development and issues in the development of a MDM2 specific therapy. https://crowfoote433xly9.mywikiparty.com/user