Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators in the microenvironment and growing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have determined recurrent mutations in genes regulating tumor cell-microenvironment interactions, that... https://shermanf086xel2.wiki-cms.com/user